Structure of PDB 3q6w Chain A

Receptor sequence
>3q6wA (length=299) Species: 9606 (Homo sapiens) [Search protein sequence]
TVHIDLSALNPELVQAVQHVVIGPSSLIVHFNEVIGRGHFGCVYHGTLLD
NDGKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPNVLSLLGICLRS
EGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKYLASKK
FVHRDLAARNCMLDEKFTVKVADFGLARDMYDKEYYSVHNKLPVKWMALE
SLQTQKFTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLL
QPEYCPDPLYEVMLKCWHPKAEMRPSFSELVSRISAIFSTFIGEHHHHH
3D structure
PDB3q6w Structural basis for selective small molecule kinase inhibition of activated c-Met.
ChainA
Resolution1.75 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D1204 A1206 R1208 N1209 D1222
Catalytic site (residue number reindexed from 1) D155 A157 R159 N160 D173
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 Q6W A I1084 G1085 R1086 V1092 A1108 Y1159 M1160 K1161 G1163 D1164 R1208 M1211 I35 G36 R37 V43 A59 Y110 M111 K112 G114 D115 R159 M162 MOAD: Kd=27nM
PDBbind-CN: -logKd/Ki=7.57,Kd=27nM
BindingDB: IC50=85nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:3q6w, PDBe:3q6w, PDBj:3q6w
PDBsum3q6w
PubMed21247903
UniProtP08581|MET_HUMAN Hepatocyte growth factor receptor (Gene Name=MET)

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