Structure of PDB 3q53 Chain A

Receptor sequence
>3q53A (length=292) Species: 9606 (Homo sapiens) [Search protein sequence]
DEEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTAMDVATGQEVAIR
QMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAG
GSLTDVVTETCMDEGQIAAVCRECLQALEFLHSNQVIHRDIKSDNILLGM
DGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWS
LGIMAIEMIEGEPPYLNENPLRALYLIATNGTPELQNPEKLSAIFRDFLN
RCLEMDVEKRGSAKELIQHQFLKIAKPLSSLTPLIAAAKEAT
3D structure
PDB3q53 Structural insights into the autoactivation mechanism of p21-activated protein kinase
ChainA
Resolution2.09 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) D389 K391 D393 N394 D407 P416 T427
Catalytic site (residue number reindexed from 1) D140 K142 D144 N145 D158 P167 T178
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ATP A A297 R299 E345 Y346 L347 L396 A48 R50 E96 Y97 L98 L147
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:3q53, PDBe:3q53, PDBj:3q53
PDBsum3q53
PubMed22153498
UniProtQ13153|PAK1_HUMAN Serine/threonine-protein kinase PAK 1 (Gene Name=PAK1)

[Back to BioLiP]