Structure of PDB 3q4t Chain A

Receptor sequence
>3q4tA (length=305) Species: 9606 (Homo sapiens) [Search protein sequence]
LGTENLYFQSMPLQLLEVKARGRFGCVWKAQLLNEYVAVKIFPIQDKQSW
QNEYEVYSLPGMKHENILQFIGAEKRGTSVDVDLWLITAFHEKGSLSDFL
KANVVSWNELCHIAETMARGLAYLHEDIPGLKDGHKPAISHRDIKSKNVL
LKNNLTACIADFGLALKFEAGKSAGDTHGQVGTRRYMAPEVLEGAINFQR
DAFLRIDMYAMGLVLWELASRCTAADGPVDEYMLPFEEEIGQHPSLEDMQ
EVVVHKKKRPVLRDYWQKHAGMAMLCETIEECWDHDAEARLSAGCVGERI
TQMQR
3D structure
PDB3q4t Small Molecules Dorsomorphin and LDN-193189 Inhibit Myostatin/GDF8 Signaling and Promote Functional Myoblast Differentiation.
ChainA
Resolution1.96 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D322 K324 N327 D340 T362
Catalytic site (residue number reindexed from 1) D143 K145 N148 D161 T183
Enzyme Commision number 2.7.11.30: receptor protein serine/threonine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 TAK A A217 K219 L247 T267 F269 H270 E271 G273 L329 A38 K40 L68 T88 F90 H91 E92 G94 L150
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004675 transmembrane receptor protein serine/threonine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation
GO:0007178 cell surface receptor protein serine/threonine kinase signaling pathway
Cellular Component
GO:0016020 membrane

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Cellular Component
External links
PDB RCSB:3q4t, PDBe:3q4t, PDBj:3q4t
PDBsum3q4t
PubMed25368322
UniProtP27037|AVR2A_HUMAN Activin receptor type-2A (Gene Name=ACVR2A)

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