Structure of PDB 3q33 Chain A

Receptor sequence
>3q33A (length=394) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence]
MSLNDFLSSVLPVSEQFEYLSLQSIPLETHAVVTPNKDDKRVPKSTIKTQ
HFFSLFHQGKVFFSLEVYVYVTLWDEADAERLIFVSKADTNGYCNTRVSV
RDITKIILEFILSIDPNYYLQKVKPAIRSSPELISAASTPARTLRILARR
LKQSGSTVLKEQQDLYLSFTCPREILTKICLFTRPASQYLFPDSSKNSKK
HILNGEELMKWWGFILDRLLIECFQNDTQAKLRIPGEDPARVRSYLRGMK
YPLWQVGDIFTSKENSLAVYNIPLFPDDPKARFIHQLAEEDRLLKVSLSS
FWIELQERQEFKLSVTSSVMGISGYSLATPSLFPSSADVIVPKSRKQFRA
IKKYITGEEYDTEEGAIEAFTNIRDFLLLRMATNLQSLTGKREH
3D structure
PDB3q33 Structure of the Rtt109-AcCoA/Vps75 Complex and Implications for Chaperone-Mediated Histone Acetylation.
ChainA
Resolution2.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.1.48: histone acetyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A G367 E368 G357 E358
BS02 ACO A A88 T90 V100 R101 F192 P195 A196 Y199 H211 L218 W221 W222 A88 T90 V100 R101 F182 P185 A186 Y189 H201 L208 W211 W212
Gene Ontology
Molecular Function
GO:0004402 histone acetyltransferase activity
GO:0005515 protein binding
GO:0010484 histone H3 acetyltransferase activity
GO:0016740 transferase activity
GO:0032931 histone H3K56 acetyltransferase activity
GO:0036408 histone H3K14 acetyltransferase activity
GO:0043992 histone H3K9 acetyltransferase activity
GO:0043994 histone H3K23 acetyltransferase activity
GO:0044017 histone H3K27 acetyltransferase activity
GO:0061733 peptide-lysine-N-acetyltransferase activity
Biological Process
GO:0006325 chromatin organization
GO:0006334 nucleosome assembly
GO:0006355 regulation of DNA-templated transcription
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006974 DNA damage response
GO:0010468 regulation of gene expression
GO:0010526 retrotransposon silencing
GO:0033554 cellular response to stress
GO:0036211 protein modification process
GO:0043007 maintenance of rDNA
GO:1990414 replication-born double-strand break repair via sister chromatid exchange
GO:2001032 regulation of double-strand break repair via nonhomologous end joining
Cellular Component
GO:0000785 chromatin
GO:0005634 nucleus
GO:0070775 H3 histone acetyltransferase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3q33, PDBe:3q33, PDBj:3q33
PDBsum3q33
PubMed21256037
UniProtQ07794|RT109_YEAST Histone acetyltransferase RTT109 (Gene Name=RTT109)

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