Structure of PDB 3q30 Chain A

Receptor sequence
>3q30A (length=330) Species: 9606 (Homo sapiens) [Search protein sequence]
LSSSLKTCYKYLNQTSAAVIQALDGEMRNAVCIFYLVLRALDTLEDDMTI
SVEKKVPLLHNFHSFLYQPDWRFMESKEKDRQVLEDFPTISLEFRNLAEK
YQTVIADICRRMGIGMAEFLDKHVTSEQEWDKYCHYVAGLVGIGLSRLFS
ASEFEDPLVGEDTERANSMGLFLQKTNIIRDYLEDQQGGREFWPQEVWSR
YVKKLGDFAKPENIDLAVQCLNELITNALHHIPDVITYLSRLRNQSVFNF
CAIPQVMAIATLAACYNNQQVFKGAVKIRKGQAVTLMMDATNMPAVKAII
YQYMEEIYHRIPDSDPSSSKTRQIISTIRT
3D structure
PDB3q30 Discovery of a new 2-aminobenzhydrol template for highly potent squalene synthase inhibitors
ChainA
Resolution2.0 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) Y171 R218 R228 F288
Catalytic site (residue number reindexed from 1) Y133 R180 R190 F250
Enzyme Commision number 2.5.1.21: squalene synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG A D80 E83 D84 D42 E45 D46
BS02 MG A D80 D84 D42 D46
BS03 D61 A Y73 R77 D80 D84 V175 V179 G180 L183 G208 L211 Q212 F288 C289 Y35 R39 D42 D46 V137 V141 G142 L145 G170 L173 Q174 F250 C251
Gene Ontology
Molecular Function
GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups
GO:0051996 squalene synthase [NAD(P)H] activity
Biological Process
GO:0008610 lipid biosynthetic process
GO:0009058 biosynthetic process
GO:0045338 farnesyl diphosphate metabolic process

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Molecular Function
View graph for
Biological Process
External links
PDB RCSB:3q30, PDBe:3q30, PDBj:3q30
PDBsum3q30
PubMed21353782
UniProtP37268|FDFT_HUMAN Squalene synthase (Gene Name=FDFT1)

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