Structure of PDB 3q2v Chain A

Receptor sequence

>3q2vA (length=532) Species: 10090 (Mus musculus) [Search protein sequence]

DWVIPPISCPENEKGEFPKNLVQIKSNRDKETKVFYSITGQGADKPPVGV
FIIERETGWLKVTQPLDREAIAKYILYSHAVSSNGEAVEDPMEIVITVTD
QNDNRPEFTQEVFEGSVAEGAVPGTSVMKVSATDADDDVNTYNAAIAYTI
VSQDPELPHKNMFTVNRDTGVISVLTSGLDRESYPTYTLVVQAADLQGEG
LSTTAKAVITVKDINDNAPVFNPSTYQGQVPENEVNARIATLKVTDDDAP
NTPAWKAVYTVVNDPDQQFVVVTDPTTNDGILKTAKGLDFEAKQQYILHV
RVENEEPFEGSLVPSTATVTVDVVDVNEAPIFMPAERRVEVPEDFGVGQE
ITSYTAREPDTFMDQKITYRIWRDTANWLEINPETGAIFTRAEMDREDAE
HVKNSTYVALIIATDDGSPIATGTGTLLLVLLDVNDNAPIPEPRNMQFCQ
RNPQPHIITILDPDLPPNTSPFTAELTHGASVNWTIEYNDAAQESLILQP
RKDEYKIHLKLADNQNKDQVTTLDVHVCDCEG

3D structure

PDB

3q2v The extracellular architecture of adherens junctions revealed by crystal structures of type I cadherins.

Chain

Resolution

3.4 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	CA	A	E11 D67 E69 D103	E11 D67 E69 D103
BS02	CA	A	E11 E69 D100 Q101 D103 D136	E11 E69 D100 Q101 D103 D136
BS03	CA	A	N102 N104 D134 D136 N143 D195	N102 N104 D134 D136 N143 D195
BS04	CA	A	E119 D180 D216	E119 D180 D216
BS05	CA	A	E119 E182 D213 I214 D216 D248	E119 E182 D213 I214 D216 D248
BS06	CA	A	N215 N217 D246 D248 A254 N304	N215 N217 D246 D248 A254 N304
BS07	CA	A	E291 D325 V326 E328 D360	E291 D325 V326 E328 D360
BS08	CA	A	E232 D289 E291 E328	E232 D289 E291 E328
BS09	CA	A	N327 E328 P330 E358 D360 Q365 D415	N327 E328 P330 E358 D360 Q365 D415
BS10	CA	A	E343 D395 E397 D436 N437	E343 D395 E397 D436 N437
BS11	CA	A	E343 E397 D433 V434 D436 D464	E343 E397 D433 V434 D436 D464
BS12	CA	A	N435 N437 D462 D464 N468 D517	N435 N437 D462 D464 N468 D513
BS13	MAN	A	S131 A132	S131 A132
BS14	MAN	A	T204 K206	T204 K206
BS15	MAN	A	R301 P314 T316	R301 P314 T316
BS16	MAN	A	W372 I412 T422	W372 I412 T422
BS17	MAN	A	W372 G423 T424	W372 G423 T424
BS18	MAN	A	E336 T426	E336 T426

Gene Ontology

	Molecular Function
GO:0005509	calcium ion binding

	Biological Process
GO:0007155	cell adhesion
GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules
GO:0098609	cell-cell adhesion

	Cellular Component
GO:0005886	plasma membrane
GO:0016020	membrane

View graph for
Molecular Function

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Biological Process

View graph for
Cellular Component

External links

PDB	RCSB:3q2v, PDBe:3q2v, PDBj:3q2v
PDBsum	3q2v
PubMed	21300292
UniProt	P09803\|CADH1_MOUSE Cadherin-1 (Gene Name=Cdh1)

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