Structure of PDB 3q0q Chain A

Receptor sequence

>3q0qA (length=343) Species: 9606 (Homo sapiens) [Search protein sequence]

GRSRLLEDFRNNRFPNLQLRDLIGHIVEFSQDQHGSRFIQQKLERATPAE
RQMVFNEILQAAYQLMTDVFGNYVIQKFFEFGSLDQKLALATRIRGHVLP
LALQMYGCRVIQKALESISSDQQVISEMVKELDGHVLKCVKDQNGNHVVQ
KCIECVQPQSLQFIIDAFKGQVFVLSTHPYGCRVIQRILEHCTAEQTLPI
LEELHQHTEQLVQDQYGNYVIQHVLEHGRPEDKSKIVSEIRGKVLALSQH
KFASNVVEKCVTHASRAERALLIDEVCCQNDGPHSALYTMMKDQYANYVV
QKMIDMAEPAQRKIIMHKIRPHITTLRKYTYGKHILAKLEKYY

3D structure

PDB

3q0q Alternate modes of cognate RNA recognition by human PUMILIO proteins.

Chain

Resolution

2.0 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	A	Q738 R742 Q745 N777 Y778 Q781 M810 Y811 C813 R814 Q817 Q848 N849 N851 H852 Q855 Y885 R888 Q891 Y921 N923 Y924 Q927 S959 N960 E963 Y1000 N1002 Y1003 Q1006 Y1036 H1039	Q33 R37 Q40 N72 Y73 Q76 M105 Y106 C108 R109 Q112 Q143 N144 N146 H147 Q150 Y180 R183 Q186 Y216 N218 Y219 Q222 S254 N255 E258 Y295 N297 Y298 Q301 Y331 H334	PDBbind-CN: Kd=0.17nM

Gene Ontology

	Molecular Function
GO:0003723	RNA binding

View graph for
Molecular Function

External links

PDB	RCSB:3q0q, PDBe:3q0q, PDBj:3q0q
PDBsum	3q0q
PubMed	21397187
UniProt	Q8TB72\|PUM2_HUMAN Pumilio homolog 2 (Gene Name=PUM2)

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