Structure of PDB 3q06 Chain A

Receptor sequence
>3q06A (length=231) Species: 9606 (Homo sapiens) [Search protein sequence]
SVPSQKTYQGSYGFRLGFLHSGTAKSVTCTYSPALNKMFVQLAKTVPVQL
YVDSTPPPGTRVRAMAIYKQSQHMTEVVRRCPHHERSSDSDGLAPPQHLI
RVEGNLRAEYLDDPNTFRHSVVVPYEPPEVGSDYTTIYFKFMCNSSCMGG
MNRRPILVIITLEDSSGNLLGRDSFEVRVCACPGRDRRTEEENLRKKKTM
DGEYFTLQIRGRERFEQFRERNEALELKDAQ
3D structure
PDB3q06 An induced fit mechanism regulates p53 DNA binding kinetics to confer sequence specificity.
ChainA
Resolution3.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna A R273 A276 R280 R178 A181 R185
BS02 dna A V122 R283 V27 R188
BS03 ZN A C176 H179 C238 C242 C81 H84 C143 C147
Gene Ontology
Molecular Function
GO:0000976 transcription cis-regulatory region binding
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
GO:0006915 apoptotic process
GO:0051262 protein tetramerization
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3q06, PDBe:3q06, PDBj:3q06
PDBsum3q06
PubMed21522129
UniProtP04637|P53_HUMAN Cellular tumor antigen p53 (Gene Name=TP53)

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