Structure of PDB 3q05 Chain A

Receptor sequence
>3q05A (length=234) Species: 9606 (Homo sapiens) [Search protein sequence]
SSSVPSQKTYQGSYGFRLGFLHSGTAKSVTCTYSPALNKMFVQLAKTVPV
QLYVDSTPPPGTRVRAMAIYKQSQHMTEVVRRCPHHERSSDSDGLAPPQH
LIRVEGNLRAEYLDDPNTFRHSVVVPYEPPEVGSDYTTIYFKFMCNSSCM
GGMNRRPILVIITLEDSSGNLLGRDSFEVRVCACPGRDRRTEEENLRKKT
MDGEYFTLQIRGRERFEQFRERNEALELKDAQAT
3D structure
PDB3q05 An induced fit mechanism regulates p53 DNA binding kinetics to confer sequence specificity.
ChainA
Resolution2.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna A S241 R248 R273 A276 R280 S148 R155 R180 A183 R187 PDBbind-CN: Kd=7.7nM
BS02 dna A V122 R248 R283 V29 R155 R190 PDBbind-CN: Kd=7.7nM
BS03 ZN A C176 H179 C238 C242 C83 H86 C145 C149
Gene Ontology
Molecular Function
GO:0000976 transcription cis-regulatory region binding
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
GO:0006915 apoptotic process
GO:0051262 protein tetramerization
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3q05, PDBe:3q05, PDBj:3q05
PDBsum3q05
PubMed21522129
UniProtP04637|P53_HUMAN Cellular tumor antigen p53 (Gene Name=TP53)

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