Structure of PDB 3px0 Chain A

Receptor sequence

>3px0A (length=557) Species: 1462 (Geobacillus kaustophilus) [Search protein sequence]

KMAFTLADRVTEEMLADKAALVVEVVEENYHDAPIVGIAVVNEHGRFFLR
PETALADPQFVAWLGDETKKKSMFDSKRAAVALKWKGIELCGVSFDLLLA
AYLLDPAQGVDDVAAAAKMKQYEAVRPDEAVYGKGAKRAVPDEPVLAEHL
VRKAAAIWELERPFLDELRRNEQDRLLVELEQPLSSILAEMEFAGVKVDT
KRLEQMGKELAEQLGTVEQRIYELAGQEFNINSPKQLGVILFEKLQLPVL
KKTKTGYSTSADVLEKLAPYHEIVENILHYRQLGKLQSTYIEGLLKVVRP
ATKKVHTIFNQALTQTGRLSSTEPNLQNIPIRLEEGRKIRQAFVPSESDW
LIFAADYSQIELRVLAHIAEDDNLMEAFRRDLRRQAKAVNYGIVYGISDY
GLAQNLNISRKEAAEFIERYFESFPGVKRYMENIVQEAKQKGYVTTLLHR
RRYLPDITSRNFNVRSFAERMAMNTPIQGSAADIIKKAMIDLNARLKEER
LQAHLLLQVHDELILEAPKEEMERLCRLVPEVMEQAVTLRVPLKVDYHYG
STWYDAK

3D structure

PDB

3px0 Structural evidence for the rare tautomer hypothesis of spontaneous mutagenesis.

Chain

Resolution

1.73 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

2.7.7.7: DNA-directed DNA polymerase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	dna	A	T550 K551 T552 T556 A558 R578 Q579 Y587 R615 Q624 N625 I626 P627 I628 R629 V828 H829	T253 K254 T255 T259 A261 R281 Q282 Y290 R318 Q327 N328 I329 P330 I331 R332 V509 H510
BS02	dna	A	N527 N529 S530 K582 S585 T586 T611 Q612 T613 R615 S617 S618 T619 E620 N622 G711 Y714 I716 S717 Y719 G720 R771 R789 N793 Q797	N230 N232 S233 K285 S288 T289 T314 Q315 T316 R318 S320 S321 T322 E323 N325 G392 Y395 I397 S398 Y400 G401 R452 R470 N474 Q478
BS03	DCP	A	R615 D653 Y654 S655 Q656 I657 E658 R702 K706 Y710 D830	R318 D356 Y357 S358 Q359 I360 E361 R383 K387 Y391 D511
BS04	DCP	A	E469 Q470 D471 R472 L473 L767 H768	E172 Q173 D174 R175 L176 L448 H449
BS05	MN	A	D653 Y654 D830	D356 Y357 D511

Gene Ontology

	Molecular Function
GO:0003676	nucleic acid binding
GO:0003677	DNA binding
GO:0003887	DNA-directed DNA polymerase activity
GO:0008408	3'-5' exonuclease activity

	Biological Process
GO:0006139	nucleobase-containing compound metabolic process
GO:0006260	DNA replication
GO:0006261	DNA-templated DNA replication

View graph for
Molecular Function

View graph for
Biological Process

External links

PDB	RCSB:3px0, PDBe:3px0, PDBj:3px0
PDBsum	3px0
PubMed	22006298
UniProt	Q5KWC1

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