Structure of PDB 3puq Chain A

Receptor sequence
>3puqA (length=472) Species: 6239 (Caenorhabditis elegans) [Search protein sequence]
TPKESDRCGGCGKFTNDFQWIGCDSCQTWYHFLCSGLEQFEYYLYEKFFC
PKCVPHTGHSIRYKVVAPHRYRWYSPNEKHLGIEVGSKTWIEDFITRENT
VPSPTDDEVCIVEDGYEFRREFEKLGGADNWGKVFMVKDMDGLNMTMPKP
GFDLEDVVKIMGSDYEVDTIDVYNQSTYSMKLDTFRKLFRDTKNRPLLYN
FLSLEFSDNNEMKEIAKPPRFVQEISMVNRLWPDVYLPEDQRPKVEQFCL
AGMAGSYTDFHVDFGGSSVYYHILKGEKIFYIAAPTEQNFAAYQAHETSP
DTTTWFGDIANGAVKRVVIKEGQTLLIPAGWIHAVLTPVDSLVFGGNFLH
LGNLEMQMRVYHLENAIRKEIRSEEKFYFPNFELLHWMYMRNVLLEKITE
ANQEGSDMREQEKNIWTASQIMKAEMERWMDRELRLGPEKNAILPTDDKN
KIMISVRKQIEIQTKIQNAKNK
3D structure
PDB3puq Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of alpha-ketoglutarate-dependent dioxygenases
ChainA
Resolution2.25 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.14.11.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FE2 A H495 D497 H567 H261 D263 H333
BS02 ZN A C198 C201 H252 C255 C8 C11 H31 C34
BS03 ZN A C244 C247 C271 C274 C23 C26 C50 C53
BS04 AKG A L423 T492 H495 Y505 K512 H567 V569 L202 T258 H261 Y271 K278 H333 V335
External links
PDB RCSB:3puq, PDBe:3puq, PDBj:3puq
PDBsum3puq
PubMed21251613
UniProtQ9GYI0|KDM7_CAEEL Lysine-specific demethylase 7 homolog (Gene Name=jmjd-1.2)

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