Structure of PDB 3pt9 Chain A

Receptor sequence
>3pt9A (length=824) Species: 10090 (Mus musculus) [Search protein sequence]
SKDRISWLGQPMKIEENRTYYQKVSIDEEMLEVGDCVSVIPDDSSKPLYL
ARVTALWEDKNGQMMFHAHWFCAGTDTVLGATSDPLELFLVGECENMQLS
YIHSKVKVIYKAPSENWAMEGKTYFFQLWYNQEYARFESPPKTQPTEDNK
HKFCLSCIRLAELRQKEMPKVLEQIEEVDGRVYCSSITKNGVVYRLGDSV
YLPPEAFTFNIKVASPVKRPKKDPVNETLYPEHYRKYSLDAPEPYRIGRI
KEIHCGKKKGKVNEADIKLRLYKFYRPENTHRSYNGSYHTDINMLYWSDE
EAVVNFSDVQGRCTVEYGEDLLESIQDYSQGGPDRFYFLEAYNSKTKNFE
DPPNHARSPGIKLPKLRTLDVFSGCGGLSEGFHQAGISETLWAIEMWDPA
AQAFRLNNPGTTVFTEDCNVLLKLVMAGEVTNSLGQRLPQKGDVEMLCGG
PPCQGFSGMNRFNSRTYSKFKNSLVVSFLSYCDYYRPRFFLLENVRNFVS
YRRSMVLKLTLRCLVRMGYQCTFGVLQAGQYGVAQTRRRAIILAAAPGEK
LPLFPEPLHVFAPRACQLSVVVDDKKFVSNITRLSSGPFRTITVRDTMSD
LPEIQNGASNSEIPYNGEPLSWFQRQLRGSHYQPILRDHICKDMSPLVAA
RMRHIPLFPGSDWRDLPNIQVRLGDGVIAHKLQYTFHDVKNGYSSTGALR
GVCSCAEGKACDPESRQFSTLIPWCLPHTGNRHNHWAGLYGRLEWDGFFS
TTVTNPEPMGKQGRVLHPEQHRVVSVRECARSQGFPDSYRFFGNILDRHR
QVGNAVPPPLAKAIGLEIKLCLLS
3D structure
PDB3pt9 Structure of DNMT1-DNA complex reveals a role for autoinhibition in maintenance DNA methylation.
ChainA
Resolution2.5 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) C1229 E1269 R1313 R1315
Catalytic site (residue number reindexed from 1) C453 E493 R537 R539
Enzyme Commision number 2.1.1.37: DNA (cytosine-5-)-methyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SAH A F1148 S1149 G1153 L1154 E1171 M1172 D1193 C1194 L1250 N1580 A1581 V1582 F372 S373 G377 L378 E395 M396 D417 C418 L474 N804 A805 V806
BS02 ZN A C1479 C1481 C1487 H1504 C703 C705 C711 H728
BS03 ZN A H796 C823 C897 C900 H67 C94 C154 C157
Gene Ontology
Molecular Function
GO:0003682 chromatin binding
GO:0008168 methyltransferase activity

View graph for
Molecular Function
External links
PDB RCSB:3pt9, PDBe:3pt9, PDBj:3pt9
PDBsum3pt9
PubMed21163962
UniProtP13864|DNMT1_MOUSE DNA (cytosine-5)-methyltransferase 1 (Gene Name=Dnmt1)

[Back to BioLiP]