Structure of PDB 3pr3 Chain A

Receptor sequence

>3pr3A (length=578) Species: 36329 (Plasmodium falciparum 3D7)

NMEITNLKSYKELVTLSAEEKTKDLKDYLNDKNRSESLIKKFKNFYMDLS
RQRYSEKTLNKLVEYAEEVELKKKVEKTFMGEKVNMTENRSVLHTALRIP
IEKINTHKIIIDNKNVLEDVHGVLKKIEKYSDDIRNGVIKTCKNTKFKNV
ICIGIGGSYLGTEFVYEAMKYYYYNMELNKNEKDQVNNFNNNYDQDNVFN
VRFLANVDPNDVNRAIQNLDQYDTLVIIISKTFTTAETMLNARSIKKWLS
LKIKDDENLSKHMVAVSTNLKLTDEFGISRDNVFEFWDWVGGRFSVTSSV
GILPLSIAFGYKNMRNFLNGCHDMDEHFLHADLKENIPVLLALTSFYNSH
FFDYKNVAILPYFQNLLKFSAHIQQLSMESNGKSVDRNNQPIHYNTCQVY
FGEPGTNGQHSFYQLIHQGQVIPVELIGFKHSHFPIKFDKEVVSNHDELM
TNFFAQADALAIGKTYEQVKEENEKNKMSPELLTHKVFNGNRPSTLLLFD
ELNFYTCGLLLSLYESRIVAEGFLLNINSFDQWGVELGKVLAKEVRNYFN
DTRNQKKSDNTYNFNESTKILLNYYLSK

3D structure

• PDB: 3pr3 Crystal structure of Plasmodium falciparum glucose-6-phosphate isomerase (PF14_0341) in complex with fructose-6-phosphate
• Chain: A
• Resolution: 2.45 Å

Enzymatic activity

• Catalytic site (original residue number in PDB): K232 E238 G293 R294 E380 H411 K540
• Catalytic site (residue number reindexed from 1): K231 E237 G292 R293 E379 H410 K539
• Enzyme Commision number: 5.3.1.9: glucose-6-phosphate isomerase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	F6P	A	G158 S231 K232 T233 T236 Q376 E380	G157 S230 K231 T232 T235 Q375 E379

Gene Ontology

Molecular Function

• GO:0004347 glucose-6-phosphate isomerase activity
• GO:0016853 isomerase activity
• GO:0048029 monosaccharide binding
• GO:0097367 carbohydrate derivative binding

Biological Process

• GO:0006094 gluconeogenesis
• GO:0006096 glycolytic process
• GO:0006098 pentose-phosphate shunt
• GO:0051156 glucose 6-phosphate metabolic process
• GO:1901135 carbohydrate derivative metabolic process

Cellular Component

• GO:0005829 cytosol

External links

• PDB: RCSB:3pr3, PDBe:3pr3, PDBj:3pr3
• PDBsum: 3pr3
• UniProt: Q8ILA4