Structure of PDB 3ppi Chain A

Receptor sequence
>3ppiA (length=258) Species: 243243 (Mycobacterium avium 104) [Search protein sequence]
TIKQFEGASAIVSGGAGGLGEATVRRLHADGLGVVIADLAAEKGKALADE
LGNRAEFVSTNVTSEDSVLAAIEAANQLGRLRYAVVAHGGFGVAQRIVQR
DGSPADMGGFTKTIDLYLNGTYNVARLVAASIAAAEPRENGERGALVLTA
SIAGYEGQIGQTAYAAAKAGVIGLTIAAARDLSSAGIRVNTIAPGTMKTP
IMESVGEEALAKFAANIPFPKRLGTPDEFADAAAFLLTNGYINGEVMRLD
GAQRFTPK
3D structure
PDB3ppi Increasing the structural coverage of tuberculosis drug targets.
ChainA
Resolution2.0 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) G19 S152 Y165 K169 K199
Catalytic site (residue number reindexed from 1) G18 S151 Y164 K168 K198
Enzyme Commision number 1.1.1.178: 3-hydroxy-2-methylbutyryl-CoA dehydrogenase.
1.1.1.35: 3-hydroxyacyl-CoA dehydrogenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG A A49 G53 A56 A48 G52 A55
BS02 MG A G15 G18 G14 G17
Gene Ontology
Molecular Function
GO:0003857 3-hydroxyacyl-CoA dehydrogenase activity
GO:0016491 oxidoreductase activity
GO:0046872 metal ion binding
GO:0047015 3-hydroxy-2-methylbutyryl-CoA dehydrogenase activity

View graph for
Molecular Function
External links
PDB RCSB:3ppi, PDBe:3ppi, PDBj:3ppi
PDBsum3ppi
PubMed25613812
UniProtA0A0H3A4S5

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