Structure of PDB 3ppg Chain A

Receptor sequence
>3ppgA (length=740) Species: 5476 (Candida albicans) [Search protein sequence]
MVQSSVLGFPRIGGQRELKKITEAYWSGKATVEELLAKGKELREHNWKLQ
QKAGVDIIPSNDFSYYDQVLDLSLLFNAIPERYTKFDLAPIDVLFAMGRG
LQAAAAVDVTALEMVKWFDSNYHYVRPTFSHSTEFKLNTAAGIKPVDEFN
EAKALGVQTRPVILGPVSYLYLGKADKDSLDLEPISLLPKILPVYKELLQ
KLKEAGAEQVQIDEPVLVLDLPEAVQSKFKEAYDALVGADVPELILTTYF
GDVRPNLKAIENLPVAGFHFDFVRVPEQLDEVASILKDGQTLSAGVVDGR
NIWKTDFAKASAVVQKAIEKVGKDKVVVATSSSLLHTPVDLESETKLDAV
IKDWFSFATQKLDEVVVIAKNVSGEDVSKQLEANAASIKARSESSITNDP
KVQERLTTINEALATRKAAFPERLTEQKAKYNLPLFPTTTIGSFPQTKDI
RINRNKFAKGQITAEEYEAFINKEIETVVRFQEEIGLDVLVHGEPERNDM
VQYFGEQLNGFAFTTNGWVQSYGSRYVRPPIIVGDVSRPKAMTVKESVYA
QSITSKPMKGMLTGPVTILRWSFPRDDVSGKIQALQLGLALRDEVNDLEG
AGITVIQVDEPAIREGLPLRAGKERSDYLNWAAQSFRVATSGVENSTQIH
SHFCLDPNHIKALDADVVSIEIQEFSEYPNHIGLGRIPSKQEFVSRIEEI
LKVYPASKFWVNPDCGRGWPEVKESLTNMVEAAKEFRAKY
3D structure
PDB3ppg Structure of Candida albicans methionine synthase determined by employing surface residue mutagenesis.
ChainA
Resolution1.98 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.14: 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A H657 C659 E679 C739 H652 C654 E671 C715
Gene Ontology
Molecular Function
GO:0003871 5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity
GO:0008168 methyltransferase activity
GO:0008172 S-methyltransferase activity
GO:0008270 zinc ion binding
GO:0046872 metal ion binding
Biological Process
GO:0006555 methionine metabolic process
GO:0006696 ergosterol biosynthetic process
GO:0008652 amino acid biosynthetic process
GO:0009086 methionine biosynthetic process
GO:0019280 L-methionine biosynthetic process from homoserine via O-acetyl-L-homoserine and cystathionine
GO:0032259 methylation
GO:0034605 cellular response to heat
GO:0052553 symbiont-mediated perturbation of host immune response
GO:0071266 'de novo' L-methionine biosynthetic process
Cellular Component
GO:0005634 nucleus
GO:0009277 fungal-type cell wall
GO:0009986 cell surface
GO:0030446 hyphal cell wall
GO:0062040 fungal biofilm matrix

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:3ppg, PDBe:3ppg, PDBj:3ppg
PDBsum3ppg
PubMed21689631
UniProtP82610|METE_CANAL 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (Gene Name=MET6)

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