Structure of PDB 3ppc Chain A

Receptor sequence
>3ppcA (length=753) Species: 5476 (Candida albicans) [Search protein sequence]
QSMVQSSVLGFPRIGGQRELKKITEAYWSGKATVEELLAKGKELREHNWK
LQQKAGVDIIPSNDFSYYDQVLDLSLLFNAIPERYTKFDLAPIDVLFAMG
RGLQYYATTALEMVKWFDSNYHYVRPTFSHSTEFKLNTAAGIKPVDEFNE
AKALGVQTRPVILGPVSYLYLGKADKDSLDLEPISLLPKILPVYKELLQK
LKEAGAEQVQIDEPVLVLDLPEAVQSKFKEAYDALVGADVPELILTTYFG
DVRPNLKAIENLPVAGFHFDFVRVPEQLDEVASILKDGQTLSAGVVDGRN
IWKTDFAKASAVVQKAIEKVGKDKVVVATSSSLLHTPVDLESETKLDAVI
KDWFSFATQKLDEVVVIAKNVSGEDVSKQLEANAASIKARSESSITNDPK
VQERLTINEALATRKAAFPERLTEQKAKYNLPLFPTTTIGSFPQIRINRN
KFAKGQITAEEYEAFINKEIETVVRFQEEIGLDVLVHGEPERNDMVQYFG
EQLNGFAFTTNGWVQSYGSRYVRPPIIVGDVSRPKAMTVKESVYAQSITS
KPMKGMLTGPVTILRWSFPRDDVSGKIQALQLGLALRDEVNDLEGAGITV
IQVDEPAIREGLPLRAGKERSDYLNWAAQSFRVATSGVENSTQIHSHFCY
SDLDPNHIKALDADVVSIEFSPNYIQEFSEYPNHIGLGLFDIHSPRIPSK
QEFVSRIEEILKVYPASKFWVNPDCGLKTRGWPEVKESLTNMVEAAKEFR
AKY
3D structure
PDB3ppc Structure of Candida albicans methionine synthase determined by employing surface residue mutagenesis.
ChainA
Resolution2.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.14: 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A H657 C659 C739 H647 C649 C725
Gene Ontology
Molecular Function
GO:0003871 5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity
GO:0008168 methyltransferase activity
GO:0008172 S-methyltransferase activity
GO:0008270 zinc ion binding
GO:0046872 metal ion binding
Biological Process
GO:0006555 methionine metabolic process
GO:0006696 ergosterol biosynthetic process
GO:0008652 amino acid biosynthetic process
GO:0009086 methionine biosynthetic process
GO:0019280 L-methionine biosynthetic process from homoserine via O-acetyl-L-homoserine and cystathionine
GO:0032259 methylation
GO:0034605 cellular response to heat
GO:0052553 symbiont-mediated perturbation of host immune response
GO:0071266 'de novo' L-methionine biosynthetic process
Cellular Component
GO:0005634 nucleus
GO:0009277 fungal-type cell wall
GO:0009986 cell surface
GO:0030446 hyphal cell wall
GO:0062040 fungal biofilm matrix

View graph for
Molecular Function
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Biological Process
View graph for
Cellular Component
External links
PDB RCSB:3ppc, PDBe:3ppc, PDBj:3ppc
PDBsum3ppc
PubMed21689631
UniProtP82610|METE_CANAL 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (Gene Name=MET6)

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