Structure of PDB 3pov Chain A

Receptor sequence
>3povA (length=445) Species: 435895 (Human herpesvirus 8 type M) [Search protein sequence]
TPTPADLFSEDYLVDTLDGLTVDDQQAVLASLSFSKFLKHAKVRDWCAQA
KIQPSMPALRMAYNYFLFSKVGEFIGSEDVCNFFVDRVFGGVRLLDVASV
YAACSQMNAHQRHHICCLVERATSSQSLNPVWDALRDGIISSSKFHWAVK
QQKIFSPAFGLRCEEVVKTLLATLLHPDETNCLDYGFMQSPQNGIFGVSL
DFAANVKTFDPNCKVYEIKCRFKYTFAKMECDPIYAAYQRLYEAPGKLAL
KDFFYSISKPAVEYVGLGKLPSESDYLVAYDQEWEACPRKKRKLTPLHNL
IRECILHNSTTESDVYVLTDPQDTRGQISIKARFKANLFVNVRHSYFYQV
LLQSSIVEEYIGSPKYYIATGFFRKRGYQDPVNCTIGGDALDPHVEIPTL
LIVTPVYFPRGAKHRLLHQAANFWSRSAKDTFPYIKWDFSYLSAN
3D structure
PDB3pov Crystal structure of a KSHV-SOX-DNA complex: insights into the molecular mechanisms underlying DNase activity and host shutoff
ChainA
Resolution2.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna A R248 F249 K250 Y373 R221 F222 K223 Y346 PDBbind-CN: Kd=6uM
BS02 dna A S299 E300 K317 K318 R319 R370 S272 E273 K290 K291 R292 R343 PDBbind-CN: Kd=6uM
BS03 MG A D221 E244 D201 E217
BS04 MG A K246 C247 K219 C220
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004519 endonuclease activity
GO:0004527 exonuclease activity
GO:0005515 protein binding
GO:0046872 metal ion binding
Cellular Component
GO:0030430 host cell cytoplasm
GO:0042025 host cell nucleus

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Molecular Function
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Cellular Component
External links
PDB RCSB:3pov, PDBe:3pov, PDBj:3pov
PDBsum3pov
PubMed21421561
UniProtP88925

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