Structure of PDB 3pna Chain A

Receptor sequence
>3pnaA (length=129) Species: 9913 (Bos taurus) [Search protein sequence]
VRKVIPKDYKTMAALAKAIEKNVLFSHLDDNERSDIFDAMFPVSFIAGET
VIQQGDEGDNFYVIDQGEMDVYVNNEWATSVGEGGSFGELALIYGTPRAA
TVKAKTNVKLWGIDRDSYRRILMGSTLRK
3D structure
PDB3pna Cyclic AMP Analog Blocks Kinase Activation by Stabilizing Inactive Conformation: Conformational Selection Highlights a New Concept in Allosteric Inhibitor Design.
ChainA
Resolution1.503 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.1.37: Transferred entry: 2.7.11.1, 2.7.11.8, 2.7.11.9, 2.7.11.10, 2.7.11.11, 2.7.11.12, 2.7.11.13, 2.7.11.21, 2.7.11.22, 2.7.11.24, 2.7.11.25, 2.7.11.30 and 2.7.12.1.
Interaction with ligand
Site
#
Ligand Ligand
chain
Binding residues on receptor
(original residue number in PDB)
Binding residues on receptor
(residue number reindexed from 1)
Binding affinity
BS01 CMP A V182 V184 F198 G199 E200 L201 A202 R209 A210 V71 V73 F87 G88 E89 L90 A91 R98 A99
External links
PDB RCSB:3pna, PDBe:3pna, PDBj:3pna
PDBsum3pna
PubMed21081668
UniProtP00514|KAP0_BOVIN cAMP-dependent protein kinase type I-alpha regulatory subunit (Gene Name=PRKAR1A)

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