Structure of PDB 3pmw Chain A

Receptor sequence
>3pmwA (length=261) Species: 10116 (Rattus norvegicus) [Search protein sequence]
NKTVVVTTILESPYVMMKKNHEMLEGNERYEGYCVDLAAEIAKHCGFKYK
LTIVGDGKYGARDADTKIWNGMVGELVYGKADIAIAPLTITLVREEVIDF
SKPFMSLGISIMIKKGTPIESAEDLSKQTEIAYGTLDSGSTKEFFRRSKI
AVFDKMWTYMRSAEPSVFVRTTAEGVARVRKSKGKYAYLLESTMNEYIEQ
RKPCDTMKVGGNLDSKGYGIATPKGSSLGTPVNLAVLKLSEQGVLDKLKN
KWWYDKGECGA
3D structure
PDB3pmw Structure based evolution of a novel series of positive modulators of the AMPA receptor.
ChainA
Resolution2.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GLU A Y62 L91 T92 R97 G142 S143 T144 E194 Y59 L88 T89 R94 G139 S140 T141 E191
BS02 G69 A I93 K105 P106 S109 K219 G220 L240 I90 K102 P103 S106 K216 G217 L237
Gene Ontology
Molecular Function
GO:0015276 ligand-gated monoatomic ion channel activity
Cellular Component
GO:0016020 membrane

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Molecular Function
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Cellular Component
External links
PDB RCSB:3pmw, PDBe:3pmw, PDBj:3pmw
PDBsum3pmw
PubMed21190850
UniProtP19491|GRIA2_RAT Glutamate receptor 2 (Gene Name=Gria2)

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