Structure of PDB 3plz Chain A

Receptor sequence
>3plzA (length=231) Species: 9606 (Homo sapiens) [Search protein sequence]
SIPHLILELLKCEPDEPQVQAKIMAYLQQEKLSTFGLMCKMADQTLFSIV
EWARSSIFFRELKVDDQMKLLQNCWSELLILDHIYRQVVHGKEGSIFLVT
GQQVDYSIIASQAGATLNNLMSHAQELVAKLRSLQFDQREFVCLKFLVLF
SLDVKNLENFQLVEGVQEQVNAALLDYTMCNYPQQTEKFGQLLLRLPEIR
AISMQAEEYLYYKHLNGDVPYNNLLIEMLHA
3D structure
PDB3plz Small Molecule Agonists of the Orphan Nuclear Receptors Steroidogenic Factor-1 (SF-1, NR5A1) and Liver Receptor Homologue-1 (LRH-1, NR5A2).
ChainA
Resolution1.75 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A F354 V357 R361 M375 Q379 F47 V50 R54 M68 Q72
BS02 470 A M345 W382 I387 H390 L517 M38 W75 I80 H83 L210 BindingDB: EC50=430nM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity

View graph for
Molecular Function
External links
PDB RCSB:3plz, PDBe:3plz, PDBj:3plz
PDBsum3plz
PubMed21391689
UniProtO00482|NR5A2_HUMAN Nuclear receptor subfamily 5 group A member 2 (Gene Name=NR5A2)

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