Structure of PDB 3pls Chain A

Receptor sequence
>3plsA (length=298) Species: 9606 (Homo sapiens) [Search protein sequence]
RDLDSALLAEVKDVLIPHERVVTHSDRVIGKGHFGVVYHGEYIDQAQNRI
QCAIKSLSRITEMQQVEAFLREGLLMRGLNHPNVLALIGIMLPPEGLPHV
LLPYMCHGDLLQFIRSPQRNPTVKDLISFGLQVARGMEYLAEQKFVHRDL
AARNCMLDESFTVKVADFGLARDILDREYYSVQQHRHARLPVKWTALESL
QTYRFTTKSDVWSFGVLLWELLTRGAPPYRHIDPFDLTHFLAQGRRLPQP
EYCPDSLYQVMQQCWEADPAVRPTFRVLVGEVEQIVSALLGDHYVQLP
3D structure
PDB3pls The Crystal Structure of a Constitutively Active Mutant RON Kinase Suggests an Intramolecular Autophosphorylation Hypothesis
ChainA
Resolution2.24 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D1208 A1210 R1212 N1213 D1226 D1235
Catalytic site (residue number reindexed from 1) D149 A151 R153 N154 D167 D176
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG A N1213 D1226 N154 D167
BS02 ANP A I1088 G1089 G1091 V1096 Y1163 M1164 R1212 M1215 I29 G30 G32 V37 Y104 M105 R153 M156
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:3pls, PDBe:3pls, PDBj:3pls
PDBsum3pls
PubMed20726546
UniProtQ04912|RON_HUMAN Macrophage-stimulating protein receptor (Gene Name=MST1R)

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