Structure of PDB 3pla Chain A

Receptor sequence

>3plaA (length=375) Species: 2287 (Saccharolobus solfataricus)

KIYLIEHVIGAVAYDENGNIVDYITNPRDLGKITEELLNNEKGIPFSATV
ELLKKVNPQEVVVENEAEVPKLQALGYRVSYEPYSKVSRIFRESLPKVAI
DIKFASNEEDYYNFLHELSLEYTRRKLRSAAQKRDLLAIQAVRAMDDIDK
TINLFSERLREWYSIHFPELDKLIEDHEEYATIVSRFGDRGFLTIDSLKE
LGFNEQRINRILDAAKKSIGADISEDDLSAMRMIANTILDLYNIRRNLNN
YLEGVMKEVAPNVTALVGPALGARLLSIAGSLDELAKMPASTIQVLGAEK
ALFRALRSGGRPPKHGIIFQYPAIHTSPRWQRGKIARALAAKLAIAARVD
AFSGRFIGDQLNEQLKKRIDEIKEK

3D structure

• PDB: 3pla Structural basis for site-specific ribose methylation by box C/D RNA protein complexes.
• Chain: A
• Resolution: 3.15 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	A	R145 S293 T294 Q296 E301 F305 K377	R143 S291 T292 Q294 E299 F303 K375
BS02	rna	A	K152 E159 R160 E163 A300 A303 R306 R313 P314 P315 K316 H317 G318 F321 G335 K336 R339 A343 K344 R370	K150 E157 R158 E161 A298 A301 R304 R311 P312 P313 K314 H315 G316 F319 G333 K334 R337 A341 K342 R368
BS03	rna	A	E301 K302 F305 R309	E299 K300 F303 R307
BS04	rna	A	N155 E159 H179 Q322	N153 E157 H177 Q320

Gene Ontology

Molecular Function

• GO:0005515 protein binding
• GO:0030515 snoRNA binding

Cellular Component

• GO:0031428 box C/D methylation guide snoRNP complex
• GO:0032040 small-subunit processome

External links

• PDB: RCSB:3pla, PDBe:3pla, PDBj:3pla
• PDBsum: 3pla
• PubMed: 21270896
• UniProt: Q97ZH3