Structure of PDB 3pkm Chain A

Receptor sequence
>3pkmA (length=229) Species: 2261 (Pyrococcus furiosus) [Search protein sequence]
HHHHGSRFLIRLVAFKVPYNHQYYLQGLIYNAIKSSNPKLATYLHEVKGP
KLFTYSLFMAEKREHPYFLGYKKGFFYFSTCVPEIAEALVNGLLMNPEVR
LWDERFYLHEIKVLREPKKFNGSTFVTLSPIAVTVVYDVPPMEKEFYSII
KDDLQDKYVMAYGDKPPSEFEMEVLIAKPKRFRIKPGIYQTAWHLVFRAY
GNDDLLKVGYEVGFGEKNSLGFGMVKVEG
3D structure
PDB3pkm Interaction of the Cas6 Riboendonuclease with CRISPR RNAs: Recognition and Cleavage.
ChainA
Resolution3.103 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.-.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna A L10 R12 Y26 N27 M66 R70 H72 F86 Y153 K194 P195 K196 R197 Y205 T207 H210 E244 L9 R11 Y19 N20 M59 R63 H65 F75 Y137 K178 P179 K180 R181 Y189 T191 H194 E228
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0004519 endonuclease activity
GO:0016788 hydrolase activity, acting on ester bonds
Biological Process
GO:0043571 maintenance of CRISPR repeat elements
GO:0051607 defense response to virus

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Molecular Function
View graph for
Biological Process
External links
PDB RCSB:3pkm, PDBe:3pkm, PDBj:3pkm
PDBsum3pkm
PubMed21300293
UniProtQ8U1S4|CAS6_PYRFU CRISPR-associated endoribonuclease Cas6 (Gene Name=cas6)

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