Structure of PDB 3pj3 Chain A

Receptor sequence
>3pj3A (length=240) Species: 9606 (Homo sapiens) [Search protein sequence]
GYGSWEIDPKDLTFLKELGTGVVKYGKWRGQYDVAIKMIDEFIEEAKVMM
NLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLE
MCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFPVRWSPPEVL
MYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRP
HLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES
3D structure
PDB3pj3 Insights into the conformational flexibility of Bruton's tyrosine kinase from multiple ligand complex structures.
ChainA
Resolution1.85 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D521 A523 R525 N526 D539 F559
Catalytic site (residue number reindexed from 1) D121 A123 R125 N126 D139 F140
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 04L A A428 K430 E445 M449 T474 Y476 M477 G480 F517 L528 S538 D539 A35 K37 E45 M49 T74 Y76 M77 G80 F117 L128 S138 D139 MOAD: ic50=5.6uM
PDBbind-CN: -logKd/Ki=5.25,IC50=5.6uM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:3pj3, PDBe:3pj3, PDBj:3pj3
PDBsum3pj3
PubMed21280133
UniProtQ06187|BTK_HUMAN Tyrosine-protein kinase BTK (Gene Name=BTK)

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