Structure of PDB 3pj1 Chain A

Receptor sequence
>3pj1A (length=241) Species: 9606 (Homo sapiens) [Search protein sequence]
GYGSWEIDPKDLTFLKELGTGVVKYGKWRGQYDVAIKMISEDEFIEEAKV
MMNLSHEKLVQLYGVCTKQIFIITEYMANGCLLNYLREMRFQTQQLLEMC
KDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLFPVRWSPPEV
LMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYR
PHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES
3D structure
PDB3pj1 Insights into the conformational flexibility of Bruton's tyrosine kinase from multiple ligand complex structures.
ChainA
Resolution2.0 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D521 A523 R525 N526 D539 F559
Catalytic site (residue number reindexed from 1) D119 A121 R123 N124 D137 F141
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 LHL A L408 V416 A428 I429 K430 E445 I472 T474 M477 G480 L528 L18 V23 A35 I36 K37 E47 I72 T74 M77 G80 L126 MOAD: ic50=0.048uM
PDBbind-CN: -logKd/Ki=7.32,IC50=48nM
BS02 LHL A Y425 Q459 Y461 Y32 Q61 Y63 MOAD: ic50=0.048uM
PDBbind-CN: -logKd/Ki=7.32,IC50=48nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:3pj1, PDBe:3pj1, PDBj:3pj1
PDBsum3pj1
PubMed21280133
UniProtQ06187|BTK_HUMAN Tyrosine-protein kinase BTK (Gene Name=BTK)

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