Structure of PDB 3pgl Chain A

Receptor sequence
>3pglA (length=180) Species: 9606 (Homo sapiens) [Search protein sequence]
QYLLPEAKAQDSDKICVVIDLDETLVHSSFKPVNNADFIIPVEIDGVVHQ
VYVLKRPHVDEFLQRMGELFECVLFTASLAKYADPVADLLDKWGAFRARL
FRESCVFHRGNYVKDLSRLGRDLRRVLILDNSPASYVFHPDNAVPVASWF
DNMSDTELHDLLPFFEQLSRVDDVYSVLRQ
3D structure
PDB3pgl Selective inactivation of a human neuronal silencing phosphatase by a small molecule inhibitor.
ChainA
Resolution2.35 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.3.16: protein-serine/threonine phosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG A D96 D98 N207 D20 D22 N131
BS02 RZX A F106 Y158 R178 F30 Y82 R102 MOAD: Ki=5uM
PDBbind-CN: -logKd/Ki=5.30,Ki=5uM
Gene Ontology
Molecular Function
GO:0008420 RNA polymerase II CTD heptapeptide repeat phosphatase activity
GO:0016791 phosphatase activity

View graph for
Molecular Function
External links
PDB RCSB:3pgl, PDBe:3pgl, PDBj:3pgl
PDBsum3pgl
PubMed21348431
UniProtQ9GZU7|CTDS1_HUMAN Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 (Gene Name=CTDSP1)

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