Structure of PDB 3pfv Chain A

Receptor sequence
>3pfvA (length=302) Species: 9606 (Homo sapiens) [Search protein sequence]
RTVEKTWKLMDKVVRLCQNPKLQLKNSPPYILDILPDTYQHLRLILSKYD
DNQKLAQLSENEYFKIYIDSLMKKSKRAIRLFKEGKERMYEEQSQDRRNL
TKLSLIFSHMLAEIKAIFPNGQFQGDNFRITKADAAEFWRKFFGDKTIVP
WKVFRQCLHEVHQISSGLEAMALKSTIDLTCNDYISVFEFDIFTRLFQPW
GSILRNWNFLAVTHPGYMAFLTYDEVKARLQKYSTKPGSYIFRLSCTRLG
QWAIGYVTGDGNILQTIPHNKPLFQALIDGSREGFYLYPDGRSYNPDLTG
LA
3D structure
PDB3pfv Crystal structure of Cbl-b TKB domain in complex with EGFR pY1069 peptide
ChainA
Resolution2.27 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A S70 P71 Y266 R286 C289 T290 R291 Y299 Q308 T309 I310 K314 E326 F328 Y329 S27 P28 Y223 R243 C246 T247 R248 Y256 Q265 T266 I267 K271 E283 F285 Y286
Gene Ontology
Molecular Function
GO:0001784 phosphotyrosine residue binding
GO:0004842 ubiquitin-protein transferase activity
GO:0005509 calcium ion binding
Biological Process
GO:0007166 cell surface receptor signaling pathway
GO:0023051 regulation of signaling

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Molecular Function
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Biological Process
External links
PDB RCSB:3pfv, PDBe:3pfv, PDBj:3pfv
PDBsum3pfv
PubMed
UniProtQ13191|CBLB_HUMAN E3 ubiquitin-protein ligase CBL-B (Gene Name=CBLB)

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