Structure of PDB 3pfh Chain A

Receptor sequence
>3pfhA (length=241) Species: 1906 (Streptomyces fradiae) [Search protein sequence]
PQADYSGEIAELYDLVHQGKGKDYHREAADLAALVRRHSPKAASLLDVAC
GTGMHLRHLADSFGTVEGLELSADMLAIARRRNPDAVLHHGDMRDFSLGR
RFSAVTCMFSSIGHLAGQAELDAALERFAAHVLPDGVVVVEPWWFPENFT
PGYVAAGTVEAGGTTVTRVSHSSREGEATRIEVHYLVAGPDRGITHHEES
HRITLFTREQYERAFTAAGLSVEFMPGGPSGRGLFTGLPGA
3D structure
PDB3pfh Molecular Architecture of TylM1 from Streptomyces fradiae: An N,N-Dimethyltransferase Involved in the Production of dTDP-d-mycaminose .
ChainA
Resolution1.792 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.235: dTDP-3-amino-3,6-dideoxy-alpha-D-glucopyranose N,N-dimethyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SAH A Y14 Y22 Y33 A58 H64 E79 L80 D101 M102 F118 S120 H123 Y5 Y13 Y24 A49 H55 E70 L71 D92 M93 F109 S111 H114
BS02 T3Q A Y14 K29 F118 W152 W153 F158 T159 Y162 R177 S179 S181 R241 Y5 K20 F109 W143 W144 F149 T150 Y153 R168 S170 S172 R232
Gene Ontology
Molecular Function
GO:0008168 methyltransferase activity
GO:0008757 S-adenosylmethionine-dependent methyltransferase activity
GO:0042803 protein homodimerization activity
Biological Process
GO:0009058 biosynthetic process
GO:0017000 antibiotic biosynthetic process
GO:0032259 methylation

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Molecular Function
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Biological Process
External links
PDB RCSB:3pfh, PDBe:3pfh, PDBj:3pfh
PDBsum3pfh
PubMed21142177
UniProtP95748|TYLM1_STRFR dTDP-3-amino-3,6-dideoxy-alpha-D-glucopyranose N,N-dimethyltransferase (Gene Name=tylM1)

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