Structure of PDB 3pen Chain A

Receptor sequence
>3penA (length=403) Species: 2287 (Saccharolobus solfataricus) [Search protein sequence]
AWPKVQPEVNIGVVGHVDHGKTTLVQAITGIWTSKKLGYAETNIGVCESC
KKPEAYVTEPSCKSCGSDDEPKFLRRISFIDAPGHEVLMATMLSGAALMD
GAILVVAANEPFPQPQTREHFVALGIIGVKNLIIVQNKVDVVSKEEALSQ
YRQIKQFTKGTWAENVPIIPVSALHKINIDSLIEGIEEYIKTPYRDLSQK
PVMLVIRSFDVNKPGTQFNELKGGVIGGSIIQGLFKVDQEIKVLPGLRVE
KQGKVSYEPIFTKISSIRFGDEEFKEAKPGGLVAIGTYLDPSLTKADNLL
GSIITLADAEVPVLWNIRIKYNLLERVVGAKEMLKVDPIRAKETLMLSVG
SSTTLGIVTSVKKDEIEVELRRPVAVWSNNIRTVISRQIAGRWRMIGWGL
VEI
3D structure
PDB3pen Structure of archaeal initiation factor aIF2gamma subunit from Sulfolobus solfataricus in the GDP-bound form.
ChainA
Resolution2.3005 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D19 K22 T23 H97
Catalytic site (residue number reindexed from 1) D18 K21 T22 H85
Enzyme Commision number 3.6.5.3: protein-synthesizing GTPase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GDP A D19 G21 K22 T23 T24 N149 K150 D152 S184 L186 D18 G20 K21 T22 T23 N137 K138 D140 S172 L174
BS02 5GP A F221 V223 K234 S278 R280 A296 G298 F209 V211 K222 S266 R268 A284 G286
BS03 MG A T54 T70 T42 T58
BS04 MG A V151 V154 V139 V142
BS05 MG A E66 Y68 D192 E54 Y56 D180
Gene Ontology
Molecular Function
GO:0000049 tRNA binding
GO:0003743 translation initiation factor activity
GO:0003746 translation elongation factor activity
GO:0003924 GTPase activity
GO:0005515 protein binding
GO:0005525 GTP binding
GO:0016787 hydrolase activity
GO:0046872 metal ion binding
Biological Process
GO:0001731 formation of translation preinitiation complex
GO:0006412 translation
GO:0006413 translational initiation
GO:0006414 translational elongation

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Molecular Function
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Biological Process
External links
PDB RCSB:3pen, PDBe:3pen, PDBj:3pen
PDBsum3pen
PubMed
UniProtQ980A5|IF2G_SACS2 Translation initiation factor 2 subunit gamma (Gene Name=eif2g)

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