Structure of PDB 3pcu Chain A

Receptor sequence
>3pcuA (length=211) Species: 9606 (Homo sapiens) [Search protein sequence]
DMPVERILEAELAVEDPVTNICQAADKQLFTLVEWAKRIPHFSELPLDDQ
VILLRAGWNELLIASFSHRSIAVKDGILLATGLHVHRNSAHSAGVGAIFD
RVLTELVSKMRDMQMDKTELGCLRAIVLFNPDSKGLSNPAEVEALREKVY
ASLEAYCKHKYPEQPGRFAKLLLRLPALRSIGLKCLEHLFFFKLIGDTPI
DTFLMEMLEAP
3D structure
PDB3pcu (+)-Rutamarin as a Dual Inducer of Both GLUT4 Translocation and Expression Efficiently Ameliorates Glucose Homeostasis in Insulin-Resistant Mice.
ChainA
Resolution2.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A F277 V280 K284 Q297 V298 L301 R302 T449 F450 E453 F30 V33 K37 Q50 V51 L54 R55 T202 F203 E206
BS02 LX8 A I268 A271 A272 Q275 L309 F313 R316 L326 A327 V342 I345 C432 H435 L436 F439 I21 A24 A25 Q28 L62 F66 R69 L79 A80 V95 I98 C185 H188 L189 F192 PDBbind-CN: -logKd/Ki=5.29,Kd=5.08uM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003707 nuclear steroid receptor activity
GO:0008270 zinc ion binding
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3pcu, PDBe:3pcu, PDBj:3pcu
PDBsum3pcu
PubMed22384078
UniProtP19793|RXRA_HUMAN Retinoic acid receptor RXR-alpha (Gene Name=RXRA)

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