Structure of PDB 3pc4 Chain A

Receptor sequence
>3pc4A (length=504) Species: 7227 (Drosophila melanogaster) [Search protein sequence]
YERPADFIDPGKPSKCKWHLGTAEKSPHIHRGIAHRQQITPNILEVIGCT
PLVKLNNIPASDGIECEMYAKCEFLNPGGSVKDRIGYRMVQDAEEQGLLK
PGYTIIEPTSGNTGIGLAMACAVKGYKCIIVMPEKMSNEKVSALRTLGAK
IIRTPTEAAYDSPEGLIYVAQQLQRETPNSIVLDQYRNAGNPLAHYDGTA
AEILWQLDNKVDMIVVSAGTAGTISGIGRKIKEQVPSCQIVGVDPYGSIL
ARPAELNKTDVQFYEVEGIGYDFPPTVFDDTVVDVWTKIGDSDCFPMSRR
LNAEEGLLCGGSSGGAMHAALEHARKLKKGQRCVVILPDGIRNYMTKFVS
DNWMEARNFKEPVNEHGHWWWSLAIAELELPAPPVILKSDATVGEAIALM
KKHRVDQLPVVDQDDGSVLGVVGQETLITQIVSMNRQQSDPAIKALNKRV
IRLNESEILGKLARVLEVDPSVLILGKNPAGKVELKALATKLDVTTFIAA
GKQK
3D structure
PDB3pc4 Structural basis for substrate activation and regulation by cystathionine beta-synthase (CBS) domains in cystathionine {beta}-synthase.
ChainA
Resolution1.7 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) K88 S318
Catalytic site (residue number reindexed from 1) K82 S312
Enzyme Commision number 4.2.1.22: cystathionine beta-synthase.
Interaction with ligand
Gene Ontology
Molecular Function
GO:0004122 cystathionine beta-synthase activity
GO:0016491 oxidoreductase activity
GO:0016740 transferase activity
GO:0016829 lyase activity
GO:0046872 metal ion binding
GO:0050421 nitrite reductase (NO-forming) activity
Biological Process
GO:0006535 cysteine biosynthetic process from serine
GO:0008340 determination of adult lifespan
GO:0019343 cysteine biosynthetic process via cystathionine
GO:0019344 cysteine biosynthetic process
GO:0034976 response to endoplasmic reticulum stress
GO:0050667 homocysteine metabolic process
Cellular Component
GO:0005737 cytoplasm

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Cellular Component
External links
PDB RCSB:3pc4, PDBe:3pc4, PDBj:3pc4
PDBsum3pc4
PubMed21081698
UniProtQ9VRD9

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