Structure of PDB 3pbo Chain A

Receptor sequence
>3pboA (length=473) Species: 208964 (Pseudomonas aeruginosa PAO1) [Search protein sequence]
IPAHRGLITDRNGEPLAVSTPVTTLWANPKELMTAKERWPQLAAALGQDT
KLFADRIEQNAEREFIYLVRGLTPEQGEGVIALKVPGVYSIEEFRRFYPA
GEVVAHAVGFTDVDDRGREGIELAFDEWLAGVPGAKPGKTLALSIDLRLQ
YLAHRELRNALLENGAKAGSLVIMDVKTGEILAMTNQPTYNPNNRRNLQP
AAMRNRAMIDVFEPGSTVKPFSMSAALASGRWKPSDIVDVYPGTLQIGRY
TIRDVSRNSRQLDLTGILIKSSNVGISKIAFDIGAESIYSVMQQVGLGQD
TGLGFPGERVGNLPNHRKWPKAETATLAYGYGLSVTAIQLAHAYAALAND
GKSVPLSMTRVDRVPDGVQVISPEVASTVQGMLQQVVEAQGGVFRAQVPG
YHAAGKSGTARKNAYRSLFAGFAPATDPRIAMVVVIDEPSKAGYFGGLVS
APVFSKVMAGALRLMNVPPDNLP
3D structure
PDB3pbo Structural basis for effectiveness of siderophore-conjugated monocarbams against clinically relevant strains of Pseudomonas aeruginosa.
ChainA
Resolution1.74 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.16.4: serine-type D-Ala-D-Ala carboxypeptidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CAZ A E291 S294 V333 S349 N351 Y409 S485 G486 T487 A488 R489 Y503 E213 S216 V255 S271 N273 Y331 S407 G408 T409 A410 R411 Y415
Gene Ontology
Molecular Function
GO:0004180 carboxypeptidase activity
GO:0008658 penicillin binding
GO:0008955 peptidoglycan glycosyltransferase activity
GO:0009002 serine-type D-Ala-D-Ala carboxypeptidase activity
Biological Process
GO:0000917 division septum assembly
GO:0006508 proteolysis
GO:0008360 regulation of cell shape
GO:0009252 peptidoglycan biosynthetic process
GO:0043093 FtsZ-dependent cytokinesis
GO:0051301 cell division
GO:0071555 cell wall organization
Cellular Component
GO:0005886 plasma membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3pbo, PDBe:3pbo, PDBj:3pbo
PDBsum3pbo
PubMed21135211
UniProtG3XD46|FTSI_PSEAE Peptidoglycan D,D-transpeptidase FtsI (Gene Name=ftsI)

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