Structure of PDB 3pbl Chain A

Receptor sequence
>3pblA (length=432) Species: 9606,10665 [Search protein sequence]
YALSYCALILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADLLVATL
VMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASIWNLCAISIDRYTA
VVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPTVC
SISNPDFVIYSSVVSFYLPFGVTVLVYARIYVVLKQRRRKNIFEMLRIDE
GLRLKIYKDTEGYYTIGIGHLLTKSPSLNAAKSELDKAIGRNTNGVITKD
EAEKLFNQDVDAAVRGILRNAKLKPVYDSLDAVRRAALINMVFQMGETGV
AGFTNSLRMLQQKRWDEAAVNLAKSRWYNQTPNRAKRVITTFRTGTWDAY
GVPLREKKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQTCHVSPELYSAT
TWLGYVNSALNPVIYTTFNIEFRKAFLKILSC
3D structure
PDB3pbl Structure of the human dopamine d3 receptor in complex with a d2/d3 selective antagonist.
ChainA
Resolution2.89 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) E1011 D1020
Catalytic site (residue number reindexed from 1) E200 D209
Enzyme Commision number 3.2.1.17: lysozyme.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GLC A E1011 D1020 E1022 G1030 F1104 Q1105 E200 D209 E211 G219 F293 Q294
BS02 GLC A H1031 L1032 D1070 F1104 G1107 H220 L221 D259 F293 G296
BS03 ETQ A D110 V111 I183 S192 F345 F346 H349 Y373 D79 V80 I152 S161 F377 F378 H381 Y405
Gene Ontology
Molecular Function
GO:0003796 lysozyme activity
GO:0004930 G protein-coupled receptor activity
GO:0016798 hydrolase activity, acting on glycosyl bonds
Biological Process
GO:0007186 G protein-coupled receptor signaling pathway
GO:0009253 peptidoglycan catabolic process
GO:0016998 cell wall macromolecule catabolic process
GO:0031640 killing of cells of another organism
GO:0042742 defense response to bacterium
GO:0044659 viral release from host cell by cytolysis
Cellular Component
GO:0016020 membrane
GO:0030430 host cell cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3pbl, PDBe:3pbl, PDBj:3pbl
PDBsum3pbl
PubMed21097933
UniProtP00720|ENLYS_BPT4 Endolysin (Gene Name=E);
P35462

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