Structure of PDB 3p8n Chain A

Receptor sequence
>3p8nA (length=182) Species: 11116 (Hepatitis C virus (isolate Japanese)) [Search protein sequence]
APITAYSQQTRGLLGCIITSLTGRDKNQVDGEVQVLSTATQSFLATCVNG
VCWTVYHGAGSKTLAGPKGPITQMYTNVDQDLVGWPAPPGARSMTPCTCG
SSDLYLVTRHADVIPVRRRGDSRGSLLSPRPVSYLKGSSGGPLLCPSGHV
VGIFRAAVCTRGVAKAVDFIPVESMETTMRAS
3D structure
PDB3p8n Combined X-ray, NMR, and kinetic analyses reveal uncommon binding characteristics of the hepatitis C virus NS3-NS4A protease inhibitor BI 201335.
ChainA
Resolution1.9 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H57 D81 G137 S139
Catalytic site (residue number reindexed from 1) H57 D81 G137 S139
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
3.4.21.98: hepacivirin.
3.4.22.-
3.6.1.15: nucleoside-triphosphate phosphatase.
3.6.4.13: RNA helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A I3 T4 A5 Y6 S7 Q8 T10 R11 S20 D30 E32 V33 V35 L36 S37 K62 T63 L64 A65 I3 T4 A5 Y6 S7 Q8 T10 R11 S20 D30 E32 V33 V35 L36 S37 K62 T63 L64 A65
BS02 L4T A Y56 H57 V78 D79 D81 R123 L135 K136 S139 F154 R155 A156 A157 V158 D168 Y56 H57 V78 D79 D81 R123 L135 K136 S139 F154 R155 A156 A157 V158 D168 MOAD: Ki=0.53nM
PDBbind-CN: -logKd/Ki=9.28,Ki=0.53nM
Gene Ontology
Molecular Function
GO:0008236 serine-type peptidase activity
Biological Process
GO:0006508 proteolysis
GO:0019087 transformation of host cell by virus

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Molecular Function
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Biological Process
External links
PDB RCSB:3p8n, PDBe:3p8n, PDBj:3p8n
PDBsum3p8n
PubMed21270126
UniProtP26662|POLG_HCVJA Genome polyprotein

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