Structure of PDB 3p89 Chain A

Receptor sequence
>3p89A (length=223) Species: 9606 (Homo sapiens) [Search protein sequence]
PDQQTLLHFIMDSYNKQRMPQEITNKILKEEFSAEENFLILTEMATNHVQ
VLVEFTKKLPGFQTLDHEDQIALLKGSAVEAMFLRSAEIFNKKLPSGHSD
LLEERIRNSGISDEYITPMFSFYKSIGELKMTQEEYALLTAIVILSPDRQ
YDREAVEKLQEPLLDVLQKLCKIHQPENPQHFAELLGRLTELRTFNHHHA
EMLMSWRVNDHKFTPLLEEIWDV
3D structure
PDB3p89 Conformationally constrained farnesoid X receptor (FXR) agonists: Heteroaryl replacements of the naphthalene.
ChainA
Resolution2.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A K303 H313 I317 K321 P463 E467 K57 H67 I71 K75 P215 E219
BS02 89P A M265 T270 F284 L287 T288 A291 H294 M328 F329 R331 I335 L340 S342 Y369 H447 W454 W469 M19 T24 F38 L41 T42 A45 H48 M82 F83 R85 I89 L94 S96 Y123 H199 W206 W221 BindingDB: EC50=120nM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
GO:0032052 bile acid binding
Biological Process
GO:0006355 regulation of DNA-templated transcription
GO:0038183 bile acid signaling pathway

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Molecular Function
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Biological Process
External links
PDB RCSB:3p89, PDBe:3p89, PDBj:3p89
PDBsum3p89
PubMed21256005
UniProtQ96RI1|NR1H4_HUMAN Bile acid receptor (Gene Name=NR1H4)

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