Structure of PDB 3p5r Chain A

Receptor sequence
>3p5rA (length=750) Species: 46220 (Taxus brevifolia) [Search protein sequence]
TYQERADELVVKIKDMFNALGDGDISPSAYDTAWVARLATISSDGSEKPR
FPQALNWVFNNQLQDGSWGIESHFSLCDRLLNTTNSVIALSVWKTGHSQV
QQGAEFIAENLRLLNEEDELSPDFQIIFPALLQKAKALGINLPYDLPFIK
YLSTTREARLTDVSAAADNIPANMLNALEGLEEVIDWNKIMRFQSKDGSF
LSSPASTACVLMNTGDEKCFTFLNNLLDKFGGCVPCMYSIDLLERLSLVD
NIEHLGIGRHFKQEIKGALDYVYRHWSERGIGWGRDSLVPDLNTTALGLR
TLRMHGYNVSSDVLNNFKDENGRFFSSAGQTHVELRSVVNLFRASDLAFP
DERAMDDARKFAEPYLREALATKISTNTKLFKEIEYVVEYPWHMSIPRLE
ARSYIDSYDDNYVWQRKTLYRMPSLSNSKCLELAKLDFNIVQSLHQEELK
LLTRWWKESGMADFTRHRVAEVYFSSATFEPEYSATRIAFTKIGCLQVLF
DDMADIFATLDELKSFTEGVKRWDTSLLHEIPECMQTCFKVWFKLMEEVN
NDVVKVQGRDMLAHIRKPWELYFNCYVQEREWLEAGYIPTFEEYLKTYAI
SVGLGPCTLQPILLMGELVKDDVVEKVHYPSNMFELVSLSWRLTNDTKTY
QAEKARGQQASGIACYMKDNPGATEEDAIKHICRVVDRALKEASFEYFKP
SNDIPMGCKSFIFNLRLCVQIFYKFIDGYGIANEEIKDYIRKVYIDPIQV
3D structure
PDB3p5r Taxadiene synthase structure and evolution of modular architecture in terpene biosynthesis.
ChainA
Resolution2.247 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) R578 S587 G606 D613 D617 S713 V714 G715 R754 N757 T761 E765 Y835 D839 Y841
Catalytic site (residue number reindexed from 1) R466 S475 G494 D501 D505 S601 V602 G603 R642 N645 T649 E653 Y723 D727 Y729
Enzyme Commision number 4.2.3.17: taxadiene synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG A N757 T761 E765 N645 T649 E653
BS02 MG A D613 D617 D501 D505
BS03 MG A D613 D617 D501 D505
BS04 FGG A V584 S587 V610 D613 V714 W753 R754 N757 T761 E765 V472 S475 V498 D501 V602 W641 R642 N645 T649 E653
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0010333 terpene synthase activity
GO:0016829 lyase activity
Biological Process
GO:0016102 diterpenoid biosynthetic process

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:3p5r, PDBe:3p5r, PDBj:3p5r
PDBsum3p5r
PubMed21160477
UniProtQ41594|TASY_TAXBR Taxadiene synthase (Gene Name=TDC1)

[Back to BioLiP]