Structure of PDB 3p5p Chain A

Receptor sequence
>3p5pA (length=745) Species: 46220 (Taxus brevifolia) [Search protein sequence]
TYQERADELVVKIKDMFNALGDGDISPSAYDTAWVARLATISSDGSEKPR
FPQALNWVFNNQLQDGSWGIESHFSLCDRLLNTTNSVIALSVWKTGHSQV
QQGAEFIAENLRLLNEEDELSPDFQIIFPALLQKAKALGINLPYDLPFIK
YLSTTREARLTDVSAAADNIPANMLNALEGLEEVIDWNKIMRFQSKDGSF
LSSPASTACVLMNTGDEKCFTFLNNLLDKFGGCVPCMYSIDLLERLSLVD
NIEHLGIGRHFKQEIKGALDYVYRHWSERGIGWGRDSLVPDLNTTALGLR
TLRMHGYNVSSDVLNNFKDENGRFFSSAGQTHVELRSVVNLFRASDLAFP
DERAMDDARKFAEPYLREALATKISTNTKLFKEIEYVVEYPWHMSIPRLE
ARSYIDSYDDNYVWQRKTLYRMPSLSNSKCLELAKLDFNIVQSLHQEELK
LLTRWWKESGMADINFTRHRVAEVYFSSATFEPEYSATRIAFTKIGCLQV
LFDDMADIFATLDELKSFTEGVKRWDTSLLHEIPECMQTCFKVWFKLMEE
VNNDVVKVQGRDMLAHIRKPWELYFNCYVQEREWLEAGYIPTFEEYLKTY
AISVGLGPCTLQPILLMGELVKDDVVEKVHYPSNMFELVSLSWRLTNDTK
TYQAEKARGQQASGIACYMKDNPGATEEDAIKHICRVVDRALKEASFEYF
KPSNDIPMGCKSFIFNLRLCVQIFYKFNEEIKDYIRKVYIDPIQV
3D structure
PDB3p5p Taxadiene synthase structure and evolution of modular architecture in terpene biosynthesis.
ChainA
Resolution1.816 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) R578 S587 G606 D613 D617 S713 V714 G715 R754 N757 T761 E765 Y835
Catalytic site (residue number reindexed from 1) R468 S477 G496 D503 D507 S603 V604 G605 R644 N647 T651 E655 Y725
Enzyme Commision number 4.2.3.17: taxadiene synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG A N757 T761 E765 N647 T651 E655
BS02 A3C A F602 G606 V714 W753 N757 T761 E765 V831 F492 G496 V604 W643 N647 T651 E655 V721
BS03 A3C A R580 F834 Y835 R470 F724 Y725
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0010333 terpene synthase activity
GO:0016829 lyase activity
Biological Process
GO:0016102 diterpenoid biosynthetic process

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:3p5p, PDBe:3p5p, PDBj:3p5p
PDBsum3p5p
PubMed21160477
UniProtQ41594|TASY_TAXBR Taxadiene synthase (Gene Name=TDC1)

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