Structure of PDB 3p4e Chain A

Receptor sequence
>3p4eA (length=323) Species: 666 (Vibrio cholerae) [Search protein sequence]
DAGNALVERIKGAVKRTRRPEVMGALCELPTKYKHPVLVSGTDGVGTKLR
LALDMKKHDTIGIDLVAMCVNDLIVQGAEPLFFLDYYATGKLDVDTAAEV
ISGIADGCLQAGCALIGGETAEMPGMYEGEDYDVAGFCVGVVEKEEIIDG
SKVQVGDALIAVGSSGPHSNGYSLVRKILEVSKADKNERLAGKTIGEHLL
APTKIYIKSGLKLIAEHDIHAISHITGGGFWENIPRVLPEGTKAVIDGKS
WEWPVIFQWLQEKGNVTTHEMYRTFNCGVGLIIALPKDQANAAVALLQAE
GETAWVIGEIAAANSNEAQVEIN
3D structure
PDB3p4e Phosphoribosylformylglycinamidine cyclo-ligase from Vibrio cholerae.
ChainA
Resolution1.77 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 6.3.3.1: phosphoribosylformylglycinamidine cyclo-ligase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 AMP A D108 I124 G140 G141 E142 T143 D85 I101 G117 G118 E119 T120
Gene Ontology
Molecular Function
GO:0004637 phosphoribosylamine-glycine ligase activity
GO:0004641 phosphoribosylformylglycinamidine cyclo-ligase activity
GO:0005524 ATP binding
GO:0016874 ligase activity
Biological Process
GO:0006164 purine nucleotide biosynthetic process
GO:0006189 'de novo' IMP biosynthetic process
GO:0046084 adenine biosynthetic process
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Cellular Component
External links
PDB RCSB:3p4e, PDBe:3p4e, PDBj:3p4e
PDBsum3p4e
PubMed
UniProtQ9KPY6|PUR5_VIBCH Phosphoribosylformylglycinamidine cyclo-ligase (Gene Name=purM)

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