Structure of PDB 3p3s Chain A

Receptor sequence

>3p3sA (length=115) Species: 9606 (Homo sapiens)

PLMVKVLDAVRGSPAINVAVHVFRKAADDTWEPFASGKTSESGELHGLTT
EEEFVEGIYKVEIDTKSYWKALGISPFHEHAEVVFTANDSGPRRYTIAAL
LSPYSYSTTAVVTNP

3D structure

• PDB: 3p3s Potent kinetic stabilizers that prevent transthyretin-mediated cardiomyocyte proteotoxicity.
• Chain: A
• Resolution: 1.6 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	3M2	A	K15 L17	K5 L7	PDBbind-CN: -logKd/Ki=7.59,Kd=26nM
BS02	3M2	A	V65 E66 N98 D99 S100 G101 P102	V55 E56 N88 D89 S90 G91 P92	PDBbind-CN: -logKd/Ki=7.59,Kd=26nM

Gene Ontology

Molecular Function

• GO:0005179 hormone activity
• GO:0005515 protein binding
• GO:0042802 identical protein binding
• GO:0070324 thyroid hormone binding

Biological Process

• GO:0006144 purine nucleobase metabolic process
• GO:0007165 signal transduction

Cellular Component

• GO:0005576 extracellular region
• GO:0005615 extracellular space
• GO:0005737 cytoplasm
• GO:0035578 azurophil granule lumen
• GO:0070062 extracellular exosome

External links

• PDB: RCSB:3p3s, PDBe:3p3s, PDBj:3p3s
• PDBsum: 3p3s
• PubMed: 21865539
• UniProt: P02766|TTHY_HUMAN Transthyretin (Gene Name=TTR)