Structure of PDB 3p35 Chain A

Receptor sequence
>3p35A (length=217) Species: 9606 (Homo sapiens) [Search protein sequence]
CHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKY
GLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNS
LMKKITLLKYFRNYMSEHLLKAGANITPRRLPYLRTWFRTRSAIILHLSN
GSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELA
SRLRYARTMVDKLLSSR
3D structure
PDB3p35 From crystal packing to molecular recognition: prediction and discovery of a binding site on the surface of polo-like kinase 1
ChainA
Resolution2.09 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.11.21: polo kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A W414 D416 Y485 E488 H489 L490 L491 R516 F535 H538 K540 W43 D45 Y114 E117 H118 L119 L120 R139 F158 H161 K163
BS02 peptide A E460 Y462 E89 Y91
External links
PDB RCSB:3p35, PDBe:3p35, PDBj:3p35
PDBsum3p35
PubMed21472932
UniProtP53350|PLK1_HUMAN Serine/threonine-protein kinase PLK1 (Gene Name=PLK1)

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