Structure of PDB 3p2k Chain A

Receptor sequence
>3p2kA (length=197) Species: 562 (Escherichia coli) [Search protein sequence]
LILKGTKTVDLSKDELTEIIGQFDRVHIDLGTGDGRNIYKLAINDQNTFY
IGIDPVKENLFDISKKIIKKPSKGGLSNVVFVIAAAESLPFELKNIADSI
SILFPWGTLLEYVIKPNRDILSNVADLAKKEAHFEFVTTYKAYFLSEQYK
AELSNSGFRIDDVKELDNEYVKQFNSLWAKRLAFGRKRSFFRVSGHV
3D structure
PDB3p2k Structural basis for the methylation of A1408 in 16S rRNA by a panaminoglycoside resistance methyltransferase NpmA from a clinical isolate and analysis of the NpmA interactions with the 30S ribosomal subunit.
ChainA
Resolution2.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.180: 16S rRNA (adenine(1408)-N(1))-methyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SAM A G32 T33 N38 D55 P56 A87 E88 L104 F105 W107 L110 S195 W197 G31 T32 N37 D54 P55 A86 E87 L103 F104 W106 L109 S176 W178 PDBbind-CN: -logKd/Ki=4.70,Kd=20uM
Gene Ontology
Molecular Function
GO:0008168 methyltransferase activity
Biological Process
GO:0032259 methylation
GO:0046677 response to antibiotic

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:3p2k, PDBe:3p2k, PDBj:3p2k
PDBsum3p2k
PubMed21062819
UniProtA8C927|NPMA_ECOLX 16S rRNA (adenine(1408)-N(1))-methyltransferase (Gene Name=npmA)

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