Structure of PDB 3p2h Chain A

Receptor sequence
>3p2hA (length=184) Species: 337 (Burkholderia glumae) [Search protein sequence]
MQTFVHEAGRLPAHIAAELGSYRYRVFVEQLGWQLPSEDEKMERDQYDRD
DTVYVLGRDANGEICGCARLLPTTRPYLLQEVFPHLLADEAPRSAHVWEL
SRFAATAWSVRPMLAAAVECAARRGARQLIGVTFCSMERMFRRIGVHAHR
AGAPVSIDGRMVVACWIDIDAQTLAALDLDPALC
3D structure
PDB3p2h Small-molecule inhibitor binding to an N-acyl-homoserine lactone synthase
ChainA
Resolution2.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.1.184: acyl-homoserine-lactone synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MTA A W33 D45 L78 F83 R104 W33 D45 L78 F83 R102
BS02 NOO A F27 L31 L102 R104 F105 I142 G143 V144 T145 F146 M149 F27 L31 L100 R102 F103 I130 G131 V132 T133 F134 M137 PDBbind-CN: -logKd/Ki=5.44,Kd=3.6uM
Gene Ontology
Molecular Function
GO:0016740 transferase activity
GO:0061579 N-acyl homoserine lactone synthase activity
Biological Process
GO:0007165 signal transduction
GO:0009372 quorum sensing

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Molecular Function
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Biological Process
External links
PDB RCSB:3p2h, PDBe:3p2h, PDBj:3p2h
PDBsum3p2h
PubMed21730159
UniProtQ4VSJ8

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