Structure of PDB 3p1f Chain A

Receptor sequence
>3p1fA (length=119) Species: 9606 (Homo sapiens) [Search protein sequence]
SMRKKIFKPEELRQALMPTLEALYRQDPESLPFRQPVDPQLLGIPDYFDI
VKNPMDLSTIKRKLDTGQYQEPWQYVDDVWLMFNNAWLYNRKTSRVYKFC
SKLAEVFEQEIDPVMQSLG
3D structure
PDB3p1f Crystal structure of the bromodomain of human CREBBP in complex with a hydroquinazolin ligand
ChainA
Resolution1.63 Å
3D
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Enzymatic activity
Enzyme Commision number 2.3.1.-
2.3.1.48: histone acetyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 3PF A P1110 V1115 L1120 N1168 V1174 P32 V37 L42 N90 V96 BindingDB: Kd=310000nM,IC50=29400nM
Gene Ontology
Molecular Function
GO:0004402 histone acetyltransferase activity
Biological Process
GO:0006355 regulation of DNA-templated transcription

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Molecular Function
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Biological Process
External links
PDB RCSB:3p1f, PDBe:3p1f, PDBj:3p1f
PDBsum3p1f
PubMed
UniProtQ92793|CBP_HUMAN CREB-binding protein (Gene Name=CREBBP)

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