Structure of PDB 3p1d Chain A

Receptor sequence
>3p1dA (length=115) Species: 9606 (Homo sapiens) [Search protein sequence]
KIFKPEELRQALMPTLEALYRQDPESLPFRQPVDPQLLGIPDYFDIVKNP
MDLSTIKRKLDTGQYQEPWQYVDDVWLMFNNAWLYNRKTSRVYKFCSKLA
EVFEQEIDPVMQSLG
3D structure
PDB3p1d Histone recognition and large-scale structural analysis of the human bromodomain family.
ChainA
Resolution1.86 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.1.-
2.3.1.48: histone acetyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MB3 A V1115 N1168 V33 N86 PDBbind-CN: -logKd/Ki=2.64,IC50=2.3mM
BindingDB: IC50=2300000nM
Gene Ontology
Molecular Function
GO:0004402 histone acetyltransferase activity
Biological Process
GO:0006355 regulation of DNA-templated transcription

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Molecular Function
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Biological Process
External links
PDB RCSB:3p1d, PDBe:3p1d, PDBj:3p1d
PDBsum3p1d
PubMed22464331
UniProtQ92793|CBP_HUMAN CREB-binding protein (Gene Name=CREBBP)

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