Structure of PDB 3ozl Chain A

Receptor sequence

>3ozlA (length=116) Species: 9606 (Homo sapiens)

CPLMVKVLDAVRGSPTINVAVHVFRKAADDTWEPFASGKTSESGELHGLT
TEEEFVEGIYKVEIDTKSYWKALGISPFHEHAEVVFTANDSGPRRYTIAA
LLSPYSYSTTAVVTNP

3D structure

• PDB: 3ozl Crystal structure of human transthyretin variant A25T in complex with flufenamic acid.
• Chain: A
• Resolution: 1.9 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	FLF	A	K15 A108 V121	K6 A99 V112	BindingDB: IC50=2900nM

Gene Ontology

Molecular Function

• GO:0005179 hormone activity
• GO:0005515 protein binding
• GO:0042802 identical protein binding
• GO:0070324 thyroid hormone binding

Biological Process

• GO:0006144 purine nucleobase metabolic process
• GO:0007165 signal transduction

Cellular Component

• GO:0005576 extracellular region
• GO:0005615 extracellular space
• GO:0005737 cytoplasm
• GO:0035578 azurophil granule lumen
• GO:0070062 extracellular exosome

External links

• PDB: RCSB:3ozl, PDBe:3ozl, PDBj:3ozl
• PDBsum: 3ozl
• UniProt: P02766|TTHY_HUMAN Transthyretin (Gene Name=TTR)