Structure of PDB 3ozj Chain A

Receptor sequence
>3ozjA (length=215) Species: 9606 (Homo sapiens) [Search protein sequence]
NEDMPVERILEAELAVEPNDPVTNICQAADKQLFTLVEWAKRIPHFSELP
LDDQVILLRAGWNELLIASFSHRSIAVKDGILLATGLHVHRNSAHSAGVG
AIFDRVLTELVSKMRDMQMDKTELGCLRAIVLFNPDSKGLSNPAEVEALR
EKVYASLEAYCKHKYPEQPGRFAKLLLRLPALRSIGLKCLEHLFFFKLIG
DTPIDTFLMEMLEAP
3D structure
PDB3ozj Structure basis of bigelovin as a selective RXR agonist with a distinct binding mode
ChainA
Resolution2.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A K284 V298 R302 E453 P458 K41 V55 R59 E210 P215
BS02 BGV A I268 F313 F346 C432 L436 I25 F70 F103 C189 L193 PDBbind-CN: -logKd/Ki=5.11,Kd=7.7uM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003707 nuclear steroid receptor activity
GO:0008270 zinc ion binding
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3ozj, PDBe:3ozj, PDBj:3ozj
PDBsum3ozj
PubMed21262235
UniProtP19793|RXRA_HUMAN Retinoic acid receptor RXR-alpha (Gene Name=RXRA)

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