Structure of PDB 3oz0 Chain A

Receptor sequence
>3oz0A (length=260) Species: 9606 (Homo sapiens) [Search protein sequence]
LKAFSKHIYNAYLKNFNMTKKKARSILTAPFVIHDIETLWQAEKGLVWKQ
LVNGLPPYKEISVHVFYRCQCTTVETVRELTEFAKSIPSFSSLFLNDQVT
LLKYGVHEAIFAMLASIVNKDGLLVANGSGFVTREFLRSLRKPFSDIIEP
KFEFAVKFNALELDDSDLALFIAAIILCGDRPGLMNVPRVEAIQDTILRA
LEFHLQANHPDAQYLFPKLLQKMADLRQLVTEHAQMMQRIKKTETETSLH
PLLQEIYKDM
3D structure
PDB3oz0 Discovery of isoindoline and tetrahydroisoquinoline derivatives as potent, selective PPARδ agonists
ChainA
Resolution3.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 3OZ A F282 R284 C285 T288 T289 H323 L330 V334 V341 L353 K367 H449 M453 L469 Y473 F66 R68 C69 T72 T73 H107 L114 V118 V125 L137 K151 H233 M237 L253 Y257 BindingDB: EC50=25nM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3oz0, PDBe:3oz0, PDBj:3oz0
PDBsum3oz0
PubMed21094606
UniProtQ03181|PPARD_HUMAN Peroxisome proliferator-activated receptor delta (Gene Name=PPARD)

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