Structure of PDB 3oyp Chain A

Receptor sequence

>3oypA (length=174) Species: 11116 (Hepatitis C virus (isolate Japanese)) [Search protein sequence]

PITAYSQQTRGLLGCIITSLTGRDKNQVDGEVQVLSTATQSFLATCVNGV
CWTVYHGAGSKTLAGPKGPITQMYTNVDQDLVGWPAPPGARSMTPCTCGS
SDLYLVTRHADVIPVRRRGDSRGSLLSPRPVSYLKGSSGGPLLCPSGHVV
GIFRAAVCTRGVAKAVDFIPVESM

3D structure

PDB

3oyp Selective irreversible inhibition of a protease by targeting a noncatalytic cysteine.

Chain

Resolution

2.76 Å

3D
structure

Catalytic site residues are labeled in the structure
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Enzymatic activity

Catalytic site (original residue number in PDB)	H57 D81 G137 S139
Catalytic site (residue number reindexed from 1)	H56 D80 G136 S138
Enzyme Commision number	2.7.7.48: RNA-directed RNA polymerase. 3.4.21.98: hepacivirin. 3.4.22.- 3.6.1.15: nucleoside-triphosphate phosphatase. 3.6.4.13: RNA helicase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	peptide	A	I3 T4 A5 Y6 S7 Q8 T10 R11 C16 S20 Q28 D30 E32 V33 Q34 V35 L36 S37 K62 T63 L64 A65	I2 T3 A4 Y5 S6 Q7 T9 R10 C15 S19 Q27 D29 E31 V32 Q33 V34 L35 S36 K61 T62 L63 A64
BS02	peptide	A	H57 D81 R155 A156 A157 C159	H56 D80 R154 A155 A156 C158
BS03	peptide	A	Q41 F43 H57 L135 K136 G137 S139 F154	Q40 F42 H56 L134 K135 G136 S138 F153
BS04	ZN	A	C97 C99 C145	C96 C98 C144

Gene Ontology

	Molecular Function
GO:0008236	serine-type peptidase activity

	Biological Process
GO:0006508	proteolysis
GO:0019087	transformation of host cell by virus

View graph for
Molecular Function

View graph for
Biological Process

External links

PDB	RCSB:3oyp, PDBe:3oyp, PDBj:3oyp
PDBsum	3oyp
PubMed	21113170
UniProt	P26662\|POLG_HCVJA Genome polyprotein

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