Structure of PDB 3oy1 Chain A

Receptor sequence
>3oy1A (length=329) Species: 9606 (Homo sapiens) [Search protein sequence]
NQFYSVEVGDSTFTVLKRYQNLKPIGSGIVCAAYDAVLDRNVAIKKLSRP
FQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMEL
MDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVK
SDCTLKILDFGLVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKIL
FPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKL
FPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVW
YDPAEVEAPPEREHTIEEWKELIYKEVMN
3D structure
PDB3oy1 Highly selective c-Jun N-terminal kinase (JNK) 2 and 3 inhibitors with in vitro CNS-like pharmacokinetic properties prevent neurodegeneration.
ChainA
Resolution1.7 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D189 K191 N194 D207 T226
Catalytic site (residue number reindexed from 1) D141 K143 N146 D159 T164
Enzyme Commision number 2.7.11.24: mitogen-activated protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 589 A I70 V78 A91 K93 I124 L144 M146 M149 Q155 S193 L206 I25 V30 A43 K45 I76 L96 M98 M101 Q107 S145 L158 MOAD: ic50=0.016uM
PDBbind-CN: -logKd/Ki=7.80,IC50=16nM
BindingDB: IC50=16nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004707 MAP kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:3oy1, PDBe:3oy1, PDBj:3oy1
PDBsum3oy1
PubMed21112785
UniProtP53779|MK10_HUMAN Mitogen-activated protein kinase 10 (Gene Name=MAPK10)

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