Structure of PDB 3own Chain A

Receptor sequence
>3ownA (length=334) Species: 9606 (Homo sapiens) [Search protein sequence]
GNTTSSVILTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSR
LYTACVYHKLFDASDSSSYKHNGTELTLRYSTGTVSGFLSQDIITVGGIT
VTQMFGEVTEMPALPFMLAEFDGVVGMGFIEQAIGRVTPIFDNIISQGVL
KEDVFSFYYNRDSQSLGGQIVLGGSDPQHYEGNFHYINLIKTGVWQIQMK
GVSVGSSTLLCEDGCLALVDTGASYISGSTSSIEKLMEALGAKKRLFDYV
VKCNEGPTLPDISFHLGGKEYTLTSADYVFQESYSSKKLCTLAIHAMDIP
PPTGPTWALGATFIRKFYTEFDRRNNRIGFALAR
3D structure
PDB3own Design and synthesis of potent macrocyclic renin inhibitors.
ChainA
Resolution2.0 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D35 S38 N40 W42 Y80 D223 A226
Catalytic site (residue number reindexed from 1) D35 S38 N40 W42 Y80 D220 A223
Enzyme Commision number 3.4.23.15: renin.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 3OX A Q16 D35 G37 Y80 T82 P115 L118 F121 Q132 D223 G225 A226 S227 Y228 S230 M300 Q16 D35 G37 Y80 T82 P115 L118 F121 Q132 D220 G222 A223 S224 Y225 S227 M297 MOAD: Ki=34nM
PDBbind-CN: -logKd/Ki=7.47,Ki=34nM
Gene Ontology
Molecular Function
GO:0004190 aspartic-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:3own, PDBe:3own, PDBj:3own
PDBsum3own
PubMed21112780
UniProtP00797|RENI_HUMAN Renin (Gene Name=REN)

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